Some molecules can be addictive to humans. They can result in physical and neurological changes that result in dependency and its resulting impairment. Chemists have the duty to work at the highest levels on knowledge and awareness of the mechanisms of dependency in order to ensure that the molecules that are created do not result in human dependency and addiction.

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Economic dependency is a separate yet important issue.  Molecules should not be designed to be essential and inseparable to livelihood and wellness and embedded in systems that provide critical items like food, clean water, and medicine.

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Chemical dependency is not limited to the human species but rather can also impact other living things both animal and plant. Dependency needs to be understood such that design for variety and resilience is pursued preferably.