Less Hazardous Synthesis
While efficiency has historically served as a proxy for sustainable practices in the chemical enterprise, it is imperative that the goal of reducing the quantity of material and energy consumed is closely coupled with considerations related to the nature of that material and energy. Using less may not have the beneficial effects of reducing the overall hazard of the synthetic process depending on the nature of the feedstocks, reagents, and auxiliary chemicals.
It is imperative that these inputs and outputs, in addition to the intended product, are as inherently benign as possible. Further, the conditions under which synthetic processes are carried out should also be considered when pursuing the goal of a more sustainable chemical enterprise. This offers benefits from environmental and human health perspectives in addition to a reduction in vulnerability to chemical accidents and sabotage.