Non-Covalent Derivatives / Weak Force Transformation
Chemists have two centuries in the pursuit of mastering bond-making to great success. However, it is also true that Nature accomplishes much of its performance and functional modifications, not through covalent bonds but rather through weak-force interactions. These weak forces engage at the time and place necessary to impart the properties temporally as needed. Weak forces are also used to guide synthetic pathways in Nature.
While humans have been increasingly aware of the essential importance of weak forces, there has not been the pursuit of mastering these powerful tools such that they can be used as design levers to create the kind of functionality that is desired.