Chemists and chemical engineers know the properties, structures, and conditions that underlie explosivity, flammability, and corrosivity.  Designing molecules such they are not capable of ignition, conflagration, combustion, or explosion is something that is within the skillset of chemistry today.

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While safety has been a concern of the chemical enterprise for much of its history, this has often been accomplished through protection from the consequences of these physical hazards when they occur rather than through molecular design for reduction of intrinsic hazard. These design tools can protect from accidents as well as terrorism and sabotage vulnerability.