The exposome refers to everything an individual is exposed to starting from the time before they are born through end of life. Each of these exposures can accumulate, compound, and interact with each other and effect one’s health. Exposures include anything from one’s environment, diet, work place, and lifestyle and can affect health in a number of facets and ways. One component of the exposome is an individual’s unique physiological characteristics and genetics, which can play a major role in how an individual will react to an exposure. In terms of sustainability it becomes important to consider the potential exposures in designing any product or chemical. By better understanding the exposome we can design more sustainable and safer products and many of the harmful exposures to human health can be minimized.